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You can start using Printify or Printful with Etsy to start a Print on Demand business with a nominal investment. There are no upfront fees with Printify and Printful and Etsy charges 20 cents for product listing. However, there's a catch. It can be challenging to get noticed amidst the platform's 500 million customers. If you can spend some money on on-site advertisement, your products will gain visibility. Just a few sales will cover your ad cost and if you make half a dozen sales, yo will be on the profitable side.